解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Urothelial carcinoma (UC) is a common complication after renal replacement therapy (RRT) among Chinese end-stage renal disease (ESRD) patients. It is unclear whether there are any differences in the clinicopathologic characteristics of UC between renal transplantation (RT) and dialysis patients; such differe...
journal_title:Transplantation
pub_type: 杂志文章,收录出版
doi:10.1097/TP.0000000000000112
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:Cell-based insulin therapies can potentially improve glycemic regulation in insulin-dependent diabetic patients. Enteroendocrine cells engineered to secrete recombinant insulin have exhibited glycemic efficacy, but have been primarily studied as uncontrollable growth systems in immune incompetent mice. Furth...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000247
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:Langerhans cells (LCs) are self-renewing epidermal myeloid cells that can migrate and mature into dendritic cells. Recipient LCs that survive cytotoxic therapy given in preparation for allogeneic hematopoietic cell transplantation may prime donor T cells to mediate cutaneous graft-versus-host disease (GVHD)....
journal_title:Transplantation
pub_type: 临床试验,杂志文章
doi:10.1097/TP.0000000000000097
更新日期:2014-09-15 00:00:00
abstract:BACKGROUND:Although longer pretransplant dialysis has been associated with poor kidney transplant outcome, no data about this association exist from the current era or from Europe. We studied the association of pretransplant dialysis duration on outcomes after kidney transplantation across two different time periods. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000085
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation, leading to graft loss. Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system through inhibition of nitric oxide signaling. We postulate that CD47 blockade and prevention of nitric ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000252
更新日期:2014-08-27 00:00:00
abstract:BACKGROUND:Extracorporeal support (ECS) during organ procurement from donors after circulatory determination of death (DCDD) could increase the number of donor organs and decrease posttransplant complications. This study reports the experience of a large transplant center with controlled DCDD. METHODS:A retrospective ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000070
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:Kidney paired donation (KPD) has emerged as a viable option for renal transplant candidates with incompatible living donors. The aim of this study was to assess the "performance" of a three-site KPD program that allowed screening of multiple donors per recipient. METHODS:We reviewed retrospectively the acti...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000054
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:There is an increasing appreciation of the deleterious effects of antibody and B cells on acute and chronic transplant outcomes. Many effector functions of antibody are mediated by a family of receptors (FcγRs) that are expressed on most immune cells, including neutrophils, natural killer cells, and B cells....
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000287
更新日期:2014-08-15 00:00:00
abstract:BACKGROUND:To date, the outcomes of transplant tourism have not been reported extensively. In addition, data about the accuracy of urine cytology for the detection and the role of the BK virus (BKV) in the carcinogenesis of urothelial carcinoma (UC) after renal transplantation are lacking. METHODS:Three hundred seven ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000023
更新日期:2014-07-15 00:00:00
abstract:BACKGROUND:More than 30% of potential kidney transplant recipients have pre-existing anti-human leukocyte antigen antibodies. This subgroup has significantly lower transplant rates and increased mortality. Desensitization has become an important tool to overcome this immunological barrier. However, limited data is avai...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000442782.98131.7c
更新日期:2014-06-27 00:00:00
abstract:BACKGROUND:The strategy of evaluating every donation opportunity warrants an investigation into the financial feasibility of this practice. The purpose of this investigation is to measure resource utilization required for procurement of transplantable organs in an organ procurement organization (OPO). METHODS:Donors w...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000441093.32217.cb
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Goal tacrolimus concentrations for the prevention of rejection in sensitized renal transplant recipients are not well established. METHODS:We evaluated the association between discharge tacrolimus trough concentration and the incidence of biopsy-proven acute rejection (BPAR) in 216 moderately sensitized ren...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000149
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Waiting time to deceased donor kidney transplant varies greatly across the United States. This variation violates the final rule, a federal mandate, which demands geographic equity in organ allocation for transplantation. METHODS:Retrospective analysis of the United States Renal Data System and United Netwo...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究
doi:10.1097/01.tp.0000438623.89310.dc
更新日期:2014-05-27 00:00:00
abstract:BACKGROUND:Extended partial hepatectomy (PH) in patients is leading to portal hyperperfusion but reduced hepatic arterial perfusion (HAP), and is invariably causing focal hepatic venous outflow obstruction (FHVOO). We observed in a rat model that PH in combination with right median hepatic vein ligation (RMHV-L) caused...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0000000000000089
更新日期:2014-05-27 00:00:00
abstract::Liver transplantation (LT) is the most effective treatment for small and unresectable hepatocellular carcinomas (HCCs). With scarcity of deceased donor livers, living donor LT (LDLT) is the alternative to deceased donor LT (DDLT). Animal studies have suggested that regeneration of the partial liver graft encourages HC...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.tp.0000446266.42019.28
更新日期:2014-04-27 00:00:00
abstract::Portal vein (PV) complications after living donor liver transplant (LDLT) have been a major concern in pediatric liver transplantation. The incidence of PV complications is more in pediatric (0%-33%) than in adult recipients. Early diagnosis and treatment of PV complications may ensure optimal graft function and good ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.tp.0000446272.05687.ce
更新日期:2014-04-27 00:00:00
abstract:BACKGROUND:De novo donor HLA-specific (dnDSA) and non-HLA antibodies including antiangiotensin type 1 receptor antibodies (AT1R-abs) have been associated with antibody-mediated rejection (AMR) and decreased graft survival as well as cellular-mediated rejection (CMR) and early onset of microvasculopathy in heart transpl...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000436927.08026.a8
更新日期:2014-03-15 00:00:00
abstract:BACKGROUND:It is unclear whether ischemic preconditioning (IPC) of solid organs induces remote IPC (RIPC) in donors after brain death (DBD). METHODS:Outcomes in kidney recipients from 163 DBD in two randomized trials of liver IPC (5 min=62 and 10 min=101) were obtained retrospectively from the Scientific Registry of T...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000436926.30897.56
更新日期:2014-02-15 00:00:00
abstract::Organ donation after circulatory death (DCD) has been endorsed by the World Health Organization and is practiced worldwide. This overview examines current DCD practices, identifies problems and challenges, and suggests clinical strategies for possible improvement. Although there is uniform agreement on DCD donor candi...
journal_title:Transplantation
pub_type: 杂志文章,评审
doi:10.1097/01.TP.0000437178.48174.db
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Perioperative renal dysfunction in liver transplant recipients complicates maintenance immunosuppressive therapy, particularly in patients with hepatitis C. Calcineurin inhibitors exacerbate renal dysfunction and mammalian target-of-rapamycin inhibitors are generally avoided because of perceived perioperativ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000438635.44461.2e
更新日期:2014-01-27 00:00:00
abstract::Over the decade between 2003 and 2012, the UK has seen major changes in how organ donation and transplantation is delivered. The number of deceased organ donors has increased from 709 (12.0 per million population [pmp]) to 1,164 (18.3 pmp); this increase has been predominantly a result of an increase in donors after c...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/01.TP.0000438215.16737.68
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Extracorporeal membrane oxygenation (ECMO) and mechanical ventilation (MV) can be used as a bridge to heart-lung transplantation (HLT). The goal of this study was to determine if pretransplantation ECMO or MV affects survival in HLT. METHODS:The United Network for Organ Sharing database was reviewed for all...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a860b8
更新日期:2014-01-15 00:00:00
abstract:BACKGROUND:Conflicting data have been reported about the effect of Toxoplasma serostatus on mortality after heart transplantation. Either a positive or a negative recipient Toxoplasma serostatus was found to be associated with increased mortality. METHODS:We evaluated the effects of T. gondii infection on survival of ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a9274a
更新日期:2013-12-27 00:00:00
abstract:BACKGROUND:Ischemia-reperfusion (I/R) injury is a multifactorial phenomenon that occurs during the transplant event and frequently compromises early graft function after liver transplantation (LT). Current comprehension of molecular mechanisms and regulation processes of I/R injury lacks clarity. MicroRNA (miRNA) regul...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a20398
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:The efficiency of islet graft survival after intraportal implantation is compromised by host innate immune responses and the production of proinflammatory cytokines that cause acute cellular injury. This reaction activates intraislet nuclear factor-κB (NF-κB), causing production of gene products that have de...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a4190e
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:The once-daily (QD), prolonged-release formulation of tacrolimus has been shown to improve adherence versus twice-daily (BD) tacrolimus. Treatment nonadherence in transplant recipients has been associated with poor graft outcomes. METHODS:This open-label, parallel-group study randomized adults with end-stag...
journal_title:Transplantation
pub_type: 杂志文章,随机对照试验
doi:10.1097/TP.0b013e3182a203bd
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:Delayed graft function (DGF) after renal transplantation can be diagnosed according to several different definitions, complicating comparison between studies that use DGF as an endpoint. This is a particular problem after transplantation with kidneys from donation after circulatory death (DCD) kidneys, becau...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182a19348
更新日期:2013-11-27 00:00:00
abstract:BACKGROUND:Dendritic cells (DC) are important in the development of acute graft-versus-host disease (GVHD) after allogeneic hemopoietic cell transplantation (alloHCT). The trafficking of immature DC from blood to GVHD target organs is likely to be regulated by chemokine receptors. METHODS:We performed flow cytometry t...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829e6d5b
更新日期:2013-10-27 00:00:00
abstract:BACKGROUND:Long-term survival and functions of encapsulated islet grafts need to be evaluated in the absence of immunosuppression. The present study aimed to assess the viability and functions of macroencapsulated islets grafted in nonhuman primates without immunosuppression for 1 year. METHODS:Islet transplantations ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829e26cf
更新日期:2013-10-15 00:00:00
abstract:BACKGROUND:Focal segmental glomerulosclerosis (FSGS) recurs after kidney transplantation in more than 30% of cases and can lead to allograft loss. Serum soluble urokinase-type plasminogen activator receptor (suPAR) is implicated in the pathogenesis of native and recurrent FSGS. METHODS:We conducted a retrospective stu...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829eda4f
更新日期:2013-10-15 00:00:00
abstract:BACKGROUND:Connective tissue growth factor (CTGF) is a key mediator of tissue fibrogenesis in kidney disease. Its involvement in renal allograft fibrosis was recently demonstrated in a mouse model. METHODS:We prospectively studied the association between urinary CTGF (CTGFu) levels and renal allograft fibrosis during ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829b07e1
更新日期:2013-09-15 00:00:00
abstract:BACKGROUND:Focal segmental glomerulosclerosis (FSGS), the second leading cause of end stage renal disease in children, appears to be increasing. Moreover, posttransplantation FSGS recurrence is a major problem, and there is concern that children receiving kidneys from living donors (LD) have increased recurrence risk. ...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829c2431
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:It is unclear to what extent cancer history affects posttransplantation mortality in solid organ transplant recipients. METHODS:We identified a Swedish population-based cohort of solid organ transplant recipients in the National Patient Register 1970 to 2008 and linked it to the Cancer and Cause-of-Death Re...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854b7
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Calcineurin is a ubiquitously expressed calcium-dependent phosphatase that is inhibited by the immunosuppressant drugs cyclosporine and tacrolimus. Measuring calcineurin activity in transplant patients has been complicated by a lack of consistent correlation between drug level and enzyme activity, particular...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829acb64
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Recent insights suggest that endothelial cell (EC) activation plays a major role in renal ischemia-reperfusion (I/R) injury. Interactions between ECs and pericytes via signaling molecules, including angiopoietins, are involved in maintenance of the vascular integrity. Experimental data have shown that enhanc...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829854d5
更新日期:2013-08-15 00:00:00
abstract:BACKGROUND:Globalization and migration patterns have increased the number of donors from countries with high incidence rates of tuberculosis (TB) in low incidence countries, with the subsequent increase in risk of TB transmission to the recipients. METHODS:Retrospective cohort study, including all actual deceased dono...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e3182977adf
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. METHODS:In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Progra...
journal_title:Transplantation
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/TP.0b013e3182962cc1
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:Cyclosporine A (CsA)-associated oxidative stress has been proposed as an important mechanism of renal injury. This study was designed to examine whether N-acetylcysteine (NAC), a well-known antioxidant, affects Klotho, antiaging gene, expression and its signaling pathway in an experimental model of chronic C...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318296c9a9
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:Membrane CD30 is an important costimulatory molecule for activated T lymphocytes, and serum level of soluble CD30 (sCD30) is considered a marker for predicting outcome in kidney transplantation. METHODS:We investigated the kinetics of CD30 expression on CD4 and CD8 T-cell populations and the source of sCD30...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e318296fd69
更新日期:2013-07-27 00:00:00
abstract:BACKGROUND:BK virus-associated nephropathy (BKVN) is associated with an increased risk of graft failure. METHODS:Levels of mRNAs encoding proteins implicated in inflammation and fibrosis were measured in urine collected at the time of biopsy diagnosis of BKVN in 29 kidney graft recipients and analyzed for prognosticat...
journal_title:Transplantation
pub_type: 杂志文章
doi:10.1097/TP.0b013e31829acb38
更新日期:2013-07-27 00:00:00